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Sweat Testing: Sample Collection and Quantitative Chloride Analysis; Approved Guideline—Third Edition (C34-A3)

This new document is a updated guideline for the performance of the sweat test for the diagnosis of cystic fibrosis.
New items in this edition:

  • Microvolume procedure for sweat chloride analysis
  • Method validation for sweat chloride
  • Quality assurance for sweat collection
  • Reference ranges for infants and beyond infancy

Preview Sample Pages

Sweat testing for cystic fibrosis: standards of performance in Australasia
Coakley J, Scott S, Mackay R, Greaves R, Jolly L, Massie J, Mishra A, Bransden A, Doery JCG, Chiriano A and Robins H
Ann Clin Biochem 2009; 46: 332-337. DOI:10.1258/acb.2009.009023

Uncertainty of sweat chloride testing: does the right hand know what the left hand is doing?
Mackay RJ, Florkowski CM, George PM, Sies CW and Woods S.
Ann Clin Biochem 2008; 45: 535-538. DOI:10.1258/acb.2008.008127

Total intra-individual variation in sweat sodium and chloride concentrations for the diagnosis of cystic fibrosis.
Koerbin G, Greaves RF, Robins H, Farquhar J and Hickman PE.
Clinica Chimica Acta 2008; 393: 128-129. DOI:10.1016/j.cca.2008.02.022

Diagnosis of Cystic Fibrosis by Sweat Testing: Age-Specific Reference Intervals
Mishra A, Greaves R, Smith K, Carlin JB, Wootton A, Stirling R and Massie J.
J Pediatr 2008; 153: 758-763. DOI:10.1016/j.jpeds.2008.04.067

Guidelines for Diagnosis of Cystic Fibrosis in Newborns through Older Adults: Cystic Fibrosis Foundation Consensus Report
Farrell PM, Rosenstein BJ, White TB, Accurso FJ, Castellani C, Cutting GR, Durie PR, LeGrys VA, Massie J, Parad RB, Rock MJ and Campbell PW
J Pediatr 2008; 153: S4-S14. DOI:10.1016/j.jpeds.2008.05.005

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